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Stimulation of lymphocyte proliferation and inhibition of nitric oxide production by aqueous Urtica dioica extract
Author(s) -
Harput U. Sebnem,
Saracoglu Iclal,
Ogihara Yukio
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1686
Subject(s) - nitric oxide , urtica dioica , splenocyte , lipopolysaccharide , stimulation , in vitro , lymphocyte , pharmacology , immunology , biology , chemistry , traditional medicine , medicine , biochemistry , endocrinology
Abstract The immunomodulatory and antiinflammatory activities of aqueous Urtica dioica extract were investigated for their effect on the mitogenic response of murine splenocytes and nitric oxide production by murine peritoneal macrophages in vitro . It was found that this extract stimulated the proliferation of T‐lymphocytes and suppressed NO production in lipopolysaccharide – stimulated macrophages without affecting cell viability. Copyright © 2005 John Wiley & Sons, Ltd.