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Matrix metalloproteinase‐1 expression inhibitory compound from the whole plants of Viola ibukiana Makino
Author(s) -
Moon HyungIn,
Kim MiRan,
Cho Moon Kyun,
Park Soojie,
Chung JinHo
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1682
Subject(s) - oleanolic acid , matrix metalloproteinase , pharmacognosy , traditional medicine , fractionation , triterpenoid , chemistry , matrix metalloproteinase inhibitor , stereochemistry , biology , biochemistry , in vitro , medicine , chromatography , biological activity , alternative medicine , pathology
Bioassay‐guided fractionation has led to the isolation of two triterpenoid saponins 3‐ O ‐[ O ‐ β ‐ D ‐glucopyranosyl‐(1 → 3)‐ O ‐ β ‐ D ‐glucopyranosyl] oleanolic acid (1), and 3‐ O ‐[ O ‐ β ‐ D ‐glucopyranosyl‐(1 → 2)‐ O ‐ β ‐ D ‐glucopyranosyl] oleanolic acid (2) from the whole plants of Viola ibukiana Makino. Compound 2 showed matrix metalloproteinase‐1 expression inhibition activities in a dose‐dependent manner. Copyright © 2005 John Wiley & Sons, Ltd.