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Evaluation of antipyretic activity of Calotropis gigantea (Asclepiadaceae) in experimental animals
Author(s) -
Chitme H. R.,
Chandra Ramesh,
Kaushik Sadhna
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1672
Subject(s) - antipyretic , traditional medicine , medicine , typhoid fever , yeast , typhoid vaccine , pharmacology , biology , virology , analgesic , biochemistry
The roots of Calotropis gigantea have been used in leprosy, eczema, syphilis, elephantiasis, ulceration and cough in the Indian system of traditional medicine. The present communication evaluated its antipyretic activity by using yeast‐induced and TAB (Typhoid) vaccine‐induced pyrexia in rats and rabbits. In both yeast‐induced and TAB vaccine‐induced fever, the fever was significantly reduced and the body temperature was normalized by administration of 200 and 400 mg/kg dose intraperitoneally. Based on the results of the present study it can be concluded that the extract of C. gigantea has potential antipyretic activity against both yeast‐induced and TAB vaccine‐induced fever, indicating the possibility of developing C. gigantea as a cheaper and potent antipyretic agent. Copyright © 2005 John Wiley & Sons, Ltd.