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Comparison of the antiinflammatory effects of Drosera rotundifolia and Drosera madagascariensis in the HET‐CAM assay
Author(s) -
Paper Dietrich H.,
Karall Elisabeth,
Kremser Michaela,
Krenn Liselotte
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1666
Subject(s) - ellagic acid , ethanol , traditional medicine , in vivo , chemistry , aqueous extract , pharmacognosy , botany , biology , antioxidant , biochemistry , in vitro , polyphenol , biological activity , medicine , microbiology and biotechnology
Abstract The antiinflammatory effects of ethanol and aqueous extracts from Drosera rotundifolia and from Drosera madagascariensis were compared in vivo in the HET‐CAM assay. Both extracts from D. rotundifolia and the ethanol extract from D. madagascariensis showed remarkable efficacy at doses of 500 µg/pellet. The inhibition of the inflammation by the extracts was stronger than that by 50 µg hydrocortisone/pellet. In contrast, there was only a very weak effect observed at a dose of 500 µg/pellet of the water extract from D. madagascariensis . The chemical analyses of the extracts showed that the effect cannot be attributed to naphthoquinones, but might be due to flavonoids. Ellagic acid obviously plays an important role in the antiangiogenic effect of the Drosera extracts. Copyright © 2005 John Wiley & Sons, Ltd.