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Secondary Metabolites from Chamaedora tepejilote (Palmae) are Active against Mycobacterium tuberculosis
Author(s) -
Jiménez Adelina,
Meckes Mariana,
Alvarez Victor,
Torres Javier,
Parra Ruth
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1664
Subject(s) - antimycobacterial , squalene , ursolic acid , mycobacterium tuberculosis , farnesol , traditional medicine , tuberculosis , chemistry , stigmasterol , microbiology and biotechnology , biology , biochemistry , medicine , chromatography , pathology
Due to the emergence of multi‐drug resistant Mycobacterium tuberculosis strains, there is an urgent need to search for new antimycobacterial drugs. The present work describes the bioactivity‐guided fractionation of Chamaedora tepejilote hexane extract which led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, β ‐sitosterol and ursolic acid. Activity against Mycobacterium tuberculosis H37Rv, determined by radiorespirometric Bactec assay, showed ursolic acid, squalene and farnesol to produce a M. tuberculosis growth inhibition of 99% at a concentration of 100 µg/mL. Copyright © 2005 John Wiley & Sons, Ltd.