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Antibacterial activity of Curcuma longa L. against methicillin‐resistant Staphylococcus aureus
Author(s) -
Kim KangJu,
Yu HyeonHee,
Cha JungDan,
Seo SeJeong,
Choi NaYoung,
You YongOuk
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1660
Subject(s) - ethyl acetate , staphylococcus aureus , curcuma , antibacterial activity , antimicrobial , traditional medicine , methicillin resistant staphylococcus aureus , microbiology and biotechnology , chemistry , pharmacology , medicine , biology , bacteria , biochemistry , genetics
Methicillin‐resistant Staphylococcus aureus (MRSA) has been emerging worldwide as one of the most important hospital and community pathogens. Therefore, new agents are needed to treat MRSA associated infections. The present study investigated the antimicrobial activity of ethyl acetate, methanol and water extracts of Curcuma longa L. ( C. longa ) against MRSA. The ethyl acetate extract of C. longa demonstrated a higher antibacterial activity than the methanol extract or water extract. Since the ethyl acetate extract was more active than the other extracts, the study examined whether the ethyl acetate extract could restore the antibacterial activity of β ‐lactams and alter the MRSA invasion of human mucosal fibroblasts (HMFs). In the checkerboard test, the ethyl acetate extract of C. longa markedly lowered the MICs of ampicillin and oxacillin against MRSA. In the bacterial invasion assay, MRSA intracellular invasion was significantly decreased in the presence of 0.125–2 mg/mL of C. longa extract compared with the control group. These results suggest that the ethyl acetate extract of C. longa may have antibacterial activity and the potential to restore the effectiveness of β ‐lactams against MRSA, and inhibit the MRSA invasion of HMFs. Copyright © 2005 John Wiley & Sons, Ltd.