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Antioxidant activity of DHC‐1, an herbal formulation, in experimentally‐induced cardiac and renal damage
Author(s) -
Bafna P. A.,
Balaraman R.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1659
Subject(s) - antioxidant , pharmacognosy , traditional medicine , medicine , phytotherapy , pharmacology , biological activity , chemistry , in vitro , pathology , biochemistry , alternative medicine
DHC‐1, an herbal formulation derived from the popular plants Bacopa monniera , Emblica officinalis , Glycyrrhiza glabra , Mangifera indica and Syzygium aromaticum was studied for its antioxidant activity. The protective effect of DHC‐1 in isoproterenol‐induced myocardial infarction and cisplatin‐induced renal damage were studied. A significant reduction in the serum markers of heart and kidney damage and the extent of lipid peroxidation with a concomitant increase in the enzymatic (SOD and CAT) and non‐enzymatic antioxidants (reduced glutathione) were observed in DHC‐1 pretreated animals compared with the isoproterenol or cisplatin alone treated animals. Thus it can be concluded that DHC‐1 possesses a protective effect against both damaged heart and kidneys in rats. This beneficial effect may be attributed, at least in part, to its antioxidant activity. Copyright © 2005 John Wiley & Sons, Ltd.