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Antihyperglycaemic flavonoids from Syzygium samarangense (Blume) Merr. and Perry
Author(s) -
ResurreccionMagno Ma. Hanshella C.,
Villaseñor Irene M.,
Harada Nobuyuki,
Monde Kenji
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1658
Subject(s) - flavanone , oral administration , pharmacognosy , traditional medicine , alloxan , positive control , phenols , chemistry , pharmacology , medicine , diabetes mellitus , flavonoid , biological activity , biochemistry , in vitro , antioxidant , endocrinology
2′,4′‐Dihydroxy‐3′,5′‐dimethyl‐6′‐methoxychalcone 1, its isomeric flavanone 5‐O‐methyl‐4′‐desmethoxymatteucinol 2 and 2′4′‐dihydroxy‐6′‐methoxy‐3′‐methylchalcone 3 were isolated from the leaves of S. samarangense using a bioassay‐directed scheme. In an oral glucose tolerance test, at a dosage of 1.0 mg[sol ]20 g mouse, 1 and 2 significantly ( α = 0.05) lowered the blood glucose levels (BGLs) in glucose‐hyperglycaemic mice when administered 15 min after a glucose load. When co‐administered with glucose, only 1 showed a significant lowering of BGLs 45 min after its oral administration. When administered 15 min before glucose, none of the flavonoids showed a positive effect. Only 1 decreased significantly, at α = 0.05, the BGLs of alloxan‐diabetic mice at t = 90–150 min. Copyright © 2005 John Wiley & Sons, Ltd.