An aqueous stem bark extract of Mangifera indica (Vimang ® ) inhibits T cell proliferation and TNF‐induced activation of nuclear transcription factor NF‐ κ B

A commercial aqueous stem bark extract of Mangifera indica L. (Vimang ® ) has been reported to have antiinflammatory, immunomodulatory and antioxidant activities. The molecular basis for these diverse properties is still unknown. This study shows that a stem bark extract of M. indica inhibits early and late events in T cell activation, including CD25 cell surface expression, progression to the S‐phase of the cell cycle and proliferation in response to T cell receptor (TCR) stimulation. Moreover, the extract prevented TNF α ‐induced I κ B α degradation and the binding of NF‐ κ B to the DNA. This study may help to explain at the molecular level some of the biological activities attributed to the aqueous stem bark extract of M. indica (Vimang ® ). Copyright © 2005 John Wiley & Sons, Ltd.