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An aqueous stem bark extract of Mangifera indica (Vimang ® ) inhibits T cell proliferation and TNF‐induced activation of nuclear transcription factor NF‐ κ B
Author(s) -
Garrido Gabino,
BlancoMolina Magdalena,
Sancho Rocío,
Macho Antonio,
Delgado René,
Muñoz Eduardo
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1656
Subject(s) - mangifera , cell cycle checkpoint , transcription factor , cell growth , stimulation , stem cell , tumor necrosis factor alpha , nfkb1 , cell cycle , biology , chemistry , pharmacology , traditional medicine , microbiology and biotechnology , cell , botany , biochemistry , medicine , immunology , endocrinology , gene
A commercial aqueous stem bark extract of Mangifera indica L. (Vimang ® ) has been reported to have antiinflammatory, immunomodulatory and antioxidant activities. The molecular basis for these diverse properties is still unknown. This study shows that a stem bark extract of M. indica inhibits early and late events in T cell activation, including CD25 cell surface expression, progression to the S‐phase of the cell cycle and proliferation in response to T cell receptor (TCR) stimulation. Moreover, the extract prevented TNF α ‐induced I κ B α degradation and the binding of NF‐ κ B to the DNA. This study may help to explain at the molecular level some of the biological activities attributed to the aqueous stem bark extract of M. indica (Vimang ® ). Copyright © 2005 John Wiley & Sons, Ltd.