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Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague‐Dawley rats
Author(s) -
Bu Yungmin,
Jin Zhen Hua,
Park Sun Young,
Baek Sunkyung,
Rho Sungju,
Ha Nina,
Park Seong Kyu,
Kim Hocheol
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1649
Subject(s) - ginseng , neuroprotection , medicine , ischemia , pharmacology , traditional medicine , middle cerebral artery , tonic (physiology) , anesthesia , occlusion , cerebral ischaemia , cerebral infarction , pathology , alternative medicine
Siberian ginseng, the root and stem bark of Acanthopanax senticosus Harms, has been used as a tonic and adaptogen to strengthen qi in traditional Korean medicine. The neuroprotective effects of water extracts of A. senticosus (ASW) were investigated in transient middle cerebral artery occlusion (MCAo, 90 min occlusion, 24 h reperfusion) of Sprague‐Dawley rats. The infarct volume was significantly reduced by 36.6% after the peritoneal injection of ASW (100 mg[sol ]kg) compared with the control. In the immunohistochemical study, ASW markedly inhibited both cyclooxygenase‐2 and OX‐42 expressions in the penumbral region at 24 h after MCAo. These results suggest that A. senticosus has a neuroprotective effect by inhibiting inflammation and microglial activation in brain ischaemia. Copyright © 2005 John Wiley & Sons, Ltd.