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Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum In vivo and In vitro
Author(s) -
Verspohl Eugen J.,
Bauer Katrin,
Neddermann Eckhard
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1643
Subject(s) - cinnamomum zeylanicum , cassia , cinnamomum , insulin , bark (sound) , in vivo , in vitro , traditional medicine , phytotherapy , diabetes mellitus , pharmacognosy , potency , pharmacology , medicine , biology , chemistry , endocrinology , biological activity , botany , biochemistry , microbiology and biotechnology , ecology , alternative medicine , traditional chinese medicine , pathology , essential oil
Rats were given Cinnamomum cassia bark or extracts from Cinnamomum cassia and zeylanicum to evaluate blood glucose and plasma insulin levels in rats under various conditions. The cassia extract was superior to the zeylanicum extract. The cassia extract was slightly more efficacious than the equivalent amount of Cassia bark. A decrease in blood glucose levels was observed in a glucose tolerance test (GTT), whereas it was not obvious in rats that were not challenged by a glucose load. The elevation in plasma insulin was direct since a stimulatory in vitro effect of insulin release from INS‐1 cells (an insulin secreting cell line) was observed. Thus the cassia extract has a direct antidiabetic potency. Copyright © 2005 John Wiley & Sons, Ltd.