Premium
Cytotoxic constituents of the twigs of Simarouba glauca collected from a plot in Southern Florida
Author(s) -
RiveroCruz J. Fausto,
Lezutekong Raphael,
LoboEcheverri Tatiana,
Ito Aiko,
Mi Qiuwen,
Chai HeeByung,
Soejarto Djaja D.,
Cordell Geoffrey A.,
Pezzuto John M.,
Swanson Steven M.,
Morelli Ivano,
Kinghorn A. Douglas
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1642
Subject(s) - scopoletin , squalene , alkaloid , chemistry , traditional medicine , coumarin , botany , pharmacognosy , biology , biological activity , biochemistry , stereochemistry , in vitro , medicine , alternative medicine , pathology
Activity‐guided fractionation of a chloroform‐soluble extract of Simarouba glauca twigs collected from a plot in southern Florida, and monitored with a human epidermoid (KB) tumor cell line, afforded six canthin‐6‐one type alkaloid derivatives, canthin‐6‐one (1), 2‐methoxycanthin‐6‐one (2), 9‐methoxycanthin‐6‐one (3), 2‐hydroxycanthin‐6‐one (4), 4,5‐dimethoxycanthin‐6‐one (5) and 4,5‐dihydroxycanthin‐6‐one (6), a limonoid, melianodiol (7), an acyclic squalene‐type triterpenoid, 14‐deacetyleurylene (8), two coumarins, scopoletin (9) and fraxidin (10), and two triglycerides, triolein (11) and trilinolein (12). Among these isolates, compounds 1–4, 7 and 8 exhibited cytotoxic activity against several human cancer cell lines. 14‐Deacetyleurylene (8) was selectively active against the Lu1 human lung cancer cell line, but was inactive in an in vivo hollow fiber assay using this same cell type. Copyright © 2005 John Wiley & Sons, Ltd.