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Inhibitory effects of Ganoderma applanatum on rat lens aldose reductase and sorbitol accumulation in streptozotocin‐induced diabetic rat tissues
Author(s) -
Jung Sang Hoon,
Lee Yeon Sil,
Shim Sang Hee,
Lee Sanghyun,
Shin Kuk Hyun,
Kim Ju Sun,
Kim Yeong Shik,
Kang Sam Sik
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1638
Subject(s) - aldose reductase , polyol pathway , streptozotocin , sorbitol , aldose reductase inhibitor , endocrinology , diabetes mellitus , medicine , chemistry , pharmacology , biochemistry , biology
Aldose reductase, the key enzyme of the polyol pathway, is known to play important roles in diabetic complications. Therefore, inhibitors of aldose reductase would be potential agents for the prevention of diabetic complications. To evaluate the inhibitory potential of aldose reductase from Ganoderma applanatum (Polyporaceae), methanol (MeOH) and water extracts were tested for their effects on rat lens aldose reductase (RLAR). The effects of both extracts on streptozotocin (STZ)‐induced diabetes in rats were also investigated. The MeOH extract exhibited a potent rat lens aldose reductase (RLAR) inhibition in vitro , and showed a significant inhibition, of not only serum glucose concentrations, but also of sorbitol accumulations in the lens, red blood cells (RBC) and sciatic nerves in STZ‐induced diabetic rats. Associated with a reduction in serum glucose concentration in STZ‐induced diabetic rats, this extract was found to cause a significant glucose tolerance effect. These results suggested that G. applanatum might possess constituents with antidiabetic and inhibitory effects on diabetic complications. Copyright © 2005 John Wiley & Sons, Ltd.