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Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti‐tuberculosis drugs induced liver toxicity
Author(s) -
Tasduq S. A.,
Kaisar P.,
Gupta D. K.,
Kapahi B. K.,
Jyotsna S.,
Johri R. K.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1631
Subject(s) - rifampicin , traditional medicine , pyrazinamide , pharmacology , isoniazid , medicine , officinalis , toxicity , antioxidant , emblica officinalis , liver injury , acute toxicity , liver toxicity , pharmacognosy , in vitro , chemistry , tuberculosis , biological activity , biochemistry , pathology
The present report showed the hepatoprotective property of a 50% hydroalcoholic extract of the fruits of Emblica officinalis (fruit) (EO‐50) against antituberculosis (anti‐TB) drugs‐induced hepatic injury. The biochemical manifestations of hepatotoxicity induced by rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), either given alone or in combination were evaluated. In vitro studies were done on suspension cultures of rat hepatocytes while sub‐acute studies were carried out in rats. The hepatoprotective activity of EO‐50 was found to be due to its membrane stabilizing, antioxidative and CYP 2E1 inhibitory effects. Copyright © 2005 John Wiley & Sons, Ltd.