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Anorectic and behavioural effects of chronic Cissampelos sympodialis treatment in female and male rats
Author(s) -
Almeida R. N.,
MeloDiniz M. F. F.,
Medeiros I. A.,
QuintansJúnior L. J.,
Navarro D. S.,
Falcão A. C. G. M.,
Duarte J. C.,
BarbosaFilho J. M.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1626
Subject(s) - anorectic , open field , body weight , oral administration , medicine , food consumption , food intake , physiology , endocrinology , agricultural economics , economics
Abstract Male and female rats were treated daily for 13 weeks with an ethanol extract of Cissampelos sympodialis leaves (9, 45 and 225 mg[sol ]kg). The food consumption, body weight and behavioural effects in the open‐field test were evaluated by weekly monitoring. The results showed that the extract chronic treatment in female rats (45 and 225 mg[sol ]kg) reduced significantly the food intake and the body weight, and produced several alterations in the open‐field test. These findings indicate that repeated oral administration of the extract may produce a sex‐dependent difference in anoretic and behavioural effects. Copyright © 2005 John Wiley & Sons, Ltd.