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Fucoidan inhibits the development of proteinuria in active Heymann nephritis
Author(s) -
Zhang Quanbin,
Li Ning,
Zhao Tingting,
Qi Huimin,
Xu Zuhong,
Li Zhien
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1623
Subject(s) - fucoidan , nephritis , proteinuria , medicine , chemistry , endocrinology , polysaccharide , kidney , biochemistry
Fucoidan, the sulphated polysaccharide extracted from brown seaweed, has various biological activities. The effect of fucoidan on the formation of proteinuria and renal functions in active Heymann nephritis was investigated in this study. Active Heymann nephritis was induced by administering brush border protein of rat proximal uriniferous tubules (FX1A). Fucoidan was administered by oral intubation to Heymann nephritis rats at three doses (50, 100 and 200 mg[sol ]kg) once daily for 4 weeks. The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan at doses of 100 and 200 mg[sol ]kg. The results indicated that fucoidan has a renoprotective effect on active Heymann nephritis and is a promising therapeutic agent for nephritis. Copyright © 2005 John Wiley & Sons, Ltd.