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Reversal of LPS‐induced central and peripheral hyperalgesia by green tea extract
Author(s) -
Kaur Surinder,
Anurag A.,
Tirkey Naveen,
Chopra Kanwaljit
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1621
Subject(s) - hyperalgesia , pharmacology , green tea extract , cyclooxygenase , rofecoxib , nimesulide , chemistry , nociception , medicine , green tea , biochemistry , food science , enzyme , receptor
Tea has recently attracted a great deal of attention for its beneficial health effects. Green tea polyphenols inhibit the production of arachidonic acid metabolites and leukotrienes resulting in decreased inflammatory responses. In the present study, the effect of green tea extract (GTE) on lipopolysaccharide (LPS)‐induced thermal and behavioural hyperalgesia in mice and the possible involvement of the cyclooxygenase pathway in this paradigm was evaluated. GTE (25 mg[sol ]kg, i.p.), nimesulide (2 mg[sol ]kg, i.p.) and rofecoxib (2 mg[sol ]kg, i.p.) significantly attenuated LPS‐induced thermal and behavioural hyperalgesia but per se did not modify any of the behavioural effects. Concurrent administration of a subeffective dose of GTE (10 mg[sol ]kg, i.p.) and rofecoxib (2 mg[sol ]kg, i.p.) or nimesulide (2 mg[sol ]kg, i.p.) significantly potentiated the antinociceptive effect of GTE in both LPS‐induced thermal and behavioural hyperalgesia with nimesulide showing a more pronounced enhancing effect. Thus it can be concluded that GTE attenuates LPS‐induced central and peripheral hyperalgesia by selective inhibition of cyclooxygenase‐2 enzyme. Copyright © 2005 John Wiley & Sons, Ltd.