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Guggulu ( Commiphora mukul ) potentially ameliorates hypothyroidism in female mice
Author(s) -
Panda Sunanda,
Kar Anand
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1602
Subject(s) - traditional medicine , medicine , pharmacognosy , biology , biological activity , in vitro , biochemistry
The efficacy of guggulu, the gum resin of Commiphora mukul in regulating hypothyroidism was evaluated in female mice. In addition to estimating serum levels of thyroxine and triiodothyronine, hepatic 5′ monodeiodinase, hepatic glucose‐6‐phospatase and lipid‐peroxidation (LPO), the activities of the anti‐oxidative enzymes, superoxide dismutase (SOD) and catalase (CAT), were investigated. While 6‐n‐propyl‐2‐thiouracil (PTU, 10.00 mg[sol ]kg[sol ]d for 30 days) induced hypothyroidism in mice, as evidenced by a decrease in thyroid hormone concentration and in hepatic 5′D‐I activity, simultaneous administration of guggulu (200 mg[sol ]kg[sol ]d for 30 days) reversed this effect, indicating its potential to stimulate thyroid function. Although in PTU treated animals a marginal increase in hepatic LPO was observed, when simultaneously treated with guggulu, it was decreased. A parallel increase in the activity of endogenous antioxidants, SOD and CAT, in the latter group indicated the safe and antiperoxidative nature of the drug. These findings suggest the possible use of guggulu in the amelioration of hypothyroidism. Copyright © 2005 John Wiley & Sons, Ltd.