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Bioactive compounds from Rhodiola rosea (Crassulaceae)
Author(s) -
Ming Dong Sheng,
Hillhouse Brian J.,
Guns Emma S.,
Eberding Andy,
Xie Sherwin,
Vimalanathan Selvarani,
Towers G. H. Neil
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1597
Subject(s) - rhodiola rosea , staphylococcus aureus , cytotoxicity , rhodiola , tyrosol , chemistry , traditional medicine , crassulaceae , antibacterial activity , gallic acid , fractionation , stereochemistry , minimum inhibitory concentration , ic50 , antimicrobial , biology , biochemistry , botany , antioxidant , bacteria , chromatography , in vitro , organic chemistry , salidroside , medicine , genetics
The methanol extract of the underground part of Rhodiola rosea was found to show inhibitory activity against Staphylococcus aureus . Bioactivity‐guided fractionation of a 95% ethanol extract from the stems of R. rosea led to the isolation of five compounds: gossypetin‐7‐O‐ l ‐rhamnopyranoside (1), rhodioflavonoside (2), gallic acid (3), trans‐p‐ hydroxycinnamic acid (4) and p ‐tyrosol (5). Their structures were elucidated by UV, IR, MS and NMR data, as well as by comparison with those of the literature. Compounds 1 and 2 were evaluated for their antibacterial and antiprostate cancer cell activities. Compounds 1 and 2 exhibited activity against Staphylococcus aureus with minimum inhibitory concentrations of 50 µg/mL and 100 µg/mL, respectively. Cytotoxicity studies of 1 and 2 also displayed activity against the prostate cancer cell line with IC 50 values of 50 µg/mL and 80 µg/mL, respectively. Copyright © 2005 John Wiley & Sons, Ltd.