Anticonﬂict actions of aqueous extracts of flowers of  Achillea millefolium  L. vary according to the estrous cycle phases in Wistar rats | Zendy

MolinaHernandez M. | Zendy; TellezAlcantara N. P. | Zendy; Diaz M. A. | Zendy; Garcia J. Perez | Zendy; Lopez J. I. Olivera | Zendy; Jaramillo M. Teresa | Zendy

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Anticonﬂict actions of aqueous extracts of flowers of Achillea millefolium L. vary according to the estrous cycle phases in Wistar rats

Author(s) -

MolinaHernandez M.,

TellezAlcantara N. P.,

Diaz M. A.,

Garcia J. Perez,

Lopez J. I. Olivera,

Jaramillo M. Teresa

Publication year - 2004

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1578

Subject(s) - achillea millefolium , estrous cycle , asteraceae , pharmacognosy , traditional medicine , aqueous extract , chemistry , biology , biological activity , medicine , botany , endocrinology , in vitro , biochemistry

Anticonict‐like effects of aqueous extract of owers of Achillea millefolium L., a plant with purported anxiolytic actions, were studied in female Wistar rats during late proestrus or diestrus. During late proestrus ( p < 0.05), control rats displayed reduced conict behavior compared with diestrus. Diazepam (2.0 mg/kg; i.p.) reduced conict behavior both during late proestrus ( p < 0.05) or diestrus ( p < 0.05). Doses of 8.0 mg/kg ( p < 0.05), 10.0 mg/kg ( p < 0.05) or 12.0 mg/kg ( p < 0.05) of Achillea millefolium reduced conict behavior during late proestrus. Conversely, during diestrus, only the dose of 12.0 mg/kg ( p < 0.05) of Achillea millefolium L. reduced conict behavior. In conclusion, the anticonict‐like actions of Achillea millefolium L. may vary according to the estrous cycle phase. Copyright © 2004 John Wiley & Sons, Ltd.

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