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Anticonflict actions of aqueous extracts of flowers of Achillea millefolium L. vary according to the estrous cycle phases in Wistar rats
Author(s) -
MolinaHernandez M.,
TellezAlcantara N. P.,
Diaz M. A.,
Garcia J. Perez,
Lopez J. I. Olivera,
Jaramillo M. Teresa
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1578
Subject(s) - achillea millefolium , estrous cycle , asteraceae , pharmacognosy , traditional medicine , aqueous extract , chemistry , biology , biological activity , medicine , botany , endocrinology , in vitro , biochemistry
Anticonict‐like effects of aqueous extract of owers of Achillea millefolium L., a plant with purported anxiolytic actions, were studied in female Wistar rats during late proestrus or diestrus. During late proestrus ( p < 0.05), control rats displayed reduced conict behavior compared with diestrus. Diazepam (2.0 mg/kg; i.p.) reduced conict behavior both during late proestrus ( p < 0.05) or diestrus ( p < 0.05). Doses of 8.0 mg/kg ( p < 0.05), 10.0 mg/kg ( p < 0.05) or 12.0 mg/kg ( p < 0.05) of Achillea millefolium reduced conict behavior during late proestrus. Conversely, during diestrus, only the dose of 12.0 mg/kg ( p < 0.05) of Achillea millefolium L. reduced conict behavior. In conclusion, the anticonict‐like actions of Achillea millefolium L. may vary according to the estrous cycle phase. Copyright © 2004 John Wiley & Sons, Ltd.