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Antibacterial potentiality of Mesua ferrea Linn. flowers
Author(s) -
Mazumder Rupa,
Dastidar Sujata G.,
Basu S. P.,
Mazumder Avijit,
Singh S. K.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1572
Subject(s) - traditional medicine , bacteria , antibacterial activity , microbiology and biotechnology , spleen , dose , biology , strain (injury) , gram positive bacteria , antibiotics , medicine , pharmacology , immunology , genetics , anatomy
The antibacterial efcacy of the methanol extract of whole owers of Mesua ferrea Linn. was studied against various strains of bacteria. It could inhibit a large number of Gram‐positive and Gram‐negative bacteria at concentration ranges of 100 to 50 µg/ml, or even lower, as against vibrios and Escherichia coli . In in vivo tests, used at concentrations of 100 and 200 µg/g of body weight, it offered signicant protection to Swiss strain of albino mice when challenged with 50 MLD of a virulent strain Sulmonella typhimurium ATCC 6539. Mortality in mice due to these two dosages of the extract alone was insignicant. The extract at 200 µg/g body weight dosage, could signicantly reduce the viable count of the strain Sulmonella typhimurium ATCC 6539 in liver, spleen and heart blood of the extract treated challenged mice. Copyright © 2004 John Wiley & Sons, Ltd.