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Piperitone from Mentha longifolia var. chorodictya Rech F. reduces the nitrofurantoin resistance of strains of enterobacteriaceae
Author(s) -
Shahverdi A. R.,
Rafii F.,
Tavassoli F.,
Bagheri M.,
Attar F.,
Ghahraman A.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1566
Subject(s) - nitrofurantoin , enterobacteriaceae , biology , traditional medicine , microbiology and biotechnology , antibiotic resistance , antibiotics , medicine , escherichia coli , genetics , gene
The diluted essential oil of Mentha longifolia (L.) var. chlorodictya Rech F. foliage enhanced the bactericidal activity of nitrofurantoin decreasing the minimum inhibitory concentration (MIC) of nitrofurantoin for nitrofurantoin‐resistant strains of Enterobacteriaceae. Thin‐layer chromatography (TLC) analysis of the essential oil detected a fraction ( R f = 0.35, UV λ max of 232.5), which was the most effective in enhancement of nitrofurantoin activity. Using gas liquid chromatography and known standards, the active fraction was identied as piperitone. 1 µl of the piperitone fraction decreased the MIC of nitrofurantoin 3–20 fold for the different strains of Enterobacteriaceae tested. Copyright © 2004 John Wiley & Sons, Ltd.