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Effect of Manilkara hexandra ( Roxb .) Dubard against experimentally‐induced gastric ulcers
Author(s) -
Shah Mamta B.,
Goswami S. S.,
Santani D. D.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1565
Subject(s) - flavonoid , ethanol , ethyl acetate , chemistry , traditional medicine , pharmacognosy , oral administration , mucin , mucus , antioxidant , lipid peroxidation , pharmacology , phytotherapy , bark (sound) , biochemistry , medicine , biological activity , in vitro , biology , pathology , ecology , alternative medicine
Effects of the avonoid rich fraction of the stem bark of Manilkara hexandra (Roxb.) Dubard, have been studied on ethanol, ethanol‐indomethacin and pylorus ligated gastric ulcers in experimental animals. Oral administration of the ethyl acetate extract (extract A 3 ) inhibited the formation of gastric lesions induced by ethanol in a dose dependent manner. The protective effect of extract A 3 against ethanol induced gastric lesions was not abolished by pretreatment with indomethacin (10 mg kg −1 ). Further, extract A 3 inhibited increase in vascular permeability due to ethanol administration. Extent of lipid peroxidation was signicantly reduced in animals treated with extract. Extract A 3 also inhibited the formation of gastric ulcers induced by pylorus ligation, when administered both orally and intraperitoneally. Moreover, pretreatment with extract A 3 increased mucus production and glycoprotein content, which was evident from the rise in mucin activity and TC: PR ratio. Copyright © 2004 John Wiley & Sons, Ltd.