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Prediction of herb–drug metabolic interactions: a simulation study
Author(s) -
Zhou Shufeng,
Huang Min,
Xu Anlong,
Yang Hongyuan,
Duan Wei,
Paxton James W.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1559
Subject(s) - pharmacology , pharmacokinetics , drug , in vivo , drug interaction , drug metabolism , oral administration , cytochrome p450 , medicine , area under the curve , chemistry , metabolism , biology , microbiology and biotechnology
In vitro and in vivo studies have indicated that the induction or inhibition of cytochrome P450 (CYP) is one of the major mechanisms for some clinically important pharmacokinetic herb–drug interactions. An attempt was made to simulate the effects of herbal preparation with single or multiple CYP‐inhibiting constituents on the area of the plasma concentration‐time curve (AUC) of coadministered drug that was either a low clearance drug by intravenous (i.v.) injection or a high clearance drug by oral route. Our simulation studies indicated that the expected increase ( R c ) in the AUC of the coadministered drug by inhibiting herbal constituent(s) was dependent on the route of administration. For low clearance drug by i.v. injection, R c was generally determined by inhibition constant ( K i ), unbound inhibitor concentration ([ I ]), hepatic fraction ( f h ), number of inhibitory herbal constituents ( n ) and metabolic pathway fraction in hepatic metabolism ( f m ), while R c for a high clearance drug by oral route, R c was determined by K i , [ I ], n and f m . By varying these parameters, R c changed accordingly. It appeared likely to predict a herb–drug metabolic interaction, if the inhibiting herbal constituents could be quantitatively determined. However, many herb‐ and drug‐related factors may cause difficulties with the prediction, and thus in vivo animal and human studies are always necessary. Copyright © 2005 John Wiley & Sons, Ltd.