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Pharmacological activities of some Argyranthemum species growing in the Canary Islands
Author(s) -
Badisa R. B.,
Couladis M.,
Tsortanidou V.,
Chaudhuri S. K.,
Walker L.,
Pilarinou E.,
SantosGuerra A.,
FranciscoOrtega J.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1530
Subject(s) - brine shrimp , biology , shrimp , antimicrobial , traditional medicine , subspecies , ec50 , microorganism , botany , cancer cell lines , in vitro , bacteria , microbiology and biotechnology , ecology , cancer cell , biochemistry , cancer , medicine , genetics
Methanolic extracts of eight subspecies of genus Argyranthemum were evaluated against brine shrimps, human cancer cell lines, malarial parasites and microorganisms under in vitro conditions. In the shrimp assay, samples of A. adauctum ssp. adauctum , A. adauctum ssp. erythrocarpon and A. frutetescens ssp. succulentum were active with ED 50 values in the range of around 300 to 360 µg/ml. In the Caco‐2, HepG2 and MCF‐7 cell lines, the samples A. adauctum ssp. jacobaeifolium and A. adauctum ssp. palmensis were active with LC 50 values ranging between 80–90 µg/ml. The secondary assay results of antimalarial activity of samples, A. adauctum ssp. adauctum , A. adauctum ssp. dugourii , A. adauctum ssp. erythrocarpon and A. adauctum ssp. jacobaeifolium have IC 50 values <50 µg/ml. The samples demonstrated broad specic antimicrobial activity against ve different microorganisms. Copyright © 2004 John Wiley & Sons, Ltd.