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In vitro anti‐ β ‐secretase and dual anti‐cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia
Author(s) -
Okello Edward J.,
Savelev Sergey U.,
Perry Elaine K.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1519
Subject(s) - camellia sinensis , cholinesterase , in vitro , pharmacognosy , theaceae , traditional medicine , dementia , pharmacology , medicine , biology , chemistry , biochemistry , botany , biological activity , disease
The primary target of licensed drugs for the treatment of Alzheimer's disease is the inhibition of the enzyme acetylcholinesterase, although preventing β ‐amyloidosis is a prime target for drugs in development. The in vitro dual anti‐cholinesterase and β ‐secretase activities of Camellia sinensis L. extract (tea) is reported. Green and black tea inhibited human acetylcholinesterase (AChE) with IC 50 values of 0.03 mg/mL and 0.06 mg/mL respectively, and human butyrylcholinesterase (BuChE) with IC 50 values 0.05 mg/mL. Green tea at a nal assay concentration of 0.03 mg/mL inhibited β ‐secretase by 38%. These novel ndings suggest that tea infusions contain biologically active principles, perhaps acting synergistically, that may be used to retard the progression of the disease assuming that these principles, yet to be identied, reach the brain. Copyright © 2004 John Wiley & Sons, Ltd.