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Antiviral activities of medicinal herbs traditionally used in southern mainland China
Author(s) -
Li Yaolan,
Ooi Linda S. M.,
Wang Hua,
But Paul P. H.,
Ooi Vincent E. C.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1518
Subject(s) - traditional medicine , punica , biology , polyphenol , medicinal plants , pharmacognosy , biological activity , medicine , antioxidant , in vitro , biochemistry
The aqueous extracts from 21 medicinal herbs traditionally used in southern mainland China were screened for antiviral activities against human herpes simplex virus type 1 (HSV‐1) and human respiratory syncytial virus (RSV) using a cytopathic effect (CPE) reduction assay. Three extracts from Agrimonia pilosa , Pithecellobium clypearia and Punica granatum , respectively, showed anti‐HSV‐1 activity, which was possibly contributed by the polyphenolic compounds in the herbal extracts. Six of the extracts, from Blumea laciniata , Elephantopus scaber , Laggera pterodonta , Mussaenda pubescens , Schefera octophylla and Scutellaria indica , respectively, exhibited anti‐RSV activity with 50% inhibition (IC 50 ) concentrations ranging from 12.5 to 32 µg/mL, and selective indices (SI) ranging from 11.2 to 40. In addition to polyphenolic compounds, other constituents present in these extracts may also contribute to their anti‐RSV activity. Copyright © 2004 John Wiley & Sons, Ltd.