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Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids
Author(s) -
Slobodníková Lívia,
KoSt'álová Daniela,
Labudová Darina,
Kotulová Daniela,
Kettmann Viktor
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1517
Subject(s) - jatrorrhizine , berberine , antimicrobial , propionibacterium acnes , traditional medicine , pharmacognosy , minimum inhibitory concentration , bark (sound) , antifungal , antibacterial activity , biology , chemistry , medicine , microbiology and biotechnology , in vitro , palmatine , pharmacology , acne , biological activity , bacteria , dermatology , biochemistry , ecology , genetics
Abstract The crude extract of Mahonia aquifolium (Pursh) Nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity. Twenty strains of coagulase‐negative staphylococci and 20 strains of Propionibacterium acnes isolated from skin lesions of patients with a severe form of acne, and 20 strains of Candida sp. isolated from chronic vulvovaginal candidoses were tested for their susceptibility to crude extract and two isolated alkaloids. The minimum inhibitory concentrations obtained in this study illustrate the varying degrees of antibacterial and antifungal activity of the tested agents. The results indicate a rational basis for the traditional use of Mahonia aquifolium for localized skin and mucosal infection therapy, as well as for the possible development of a preparation for supportive therapy of the diseases mentioned above. Copyright © 2004 John Wiley & Sons, Ltd.