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Antimalarial activity of Bidens pilosa L. (Asteraceae) ethanol extracts from wild plants collected in various localities or plants cultivated in humus soil
Author(s) -
AndradeNeto Valter F.,
Brandão Maria G. L.,
Oliveira Francielda Q.,
Casali Vicente W. D.,
Njaine Brian,
Zalis Mariano G.,
Oliveira Luciana A.,
Krettli Antoniana U.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1510
Subject(s) - asteraceae , bidens pilosa , botany , biology , traditional medicine , medicine
Bidens pilosa (Asteraceae), a medicinal plant used worldwide, has antimalarial activity as shown in previous work. This study tested ethanol extracts from wild plants collected in three different regions of Brazil and from plants cultivated in various soil conditions. The extracts were active in mice infected with P. berghei : doses of ≤500 mg/kg administered by oral route reduced malaria parasitaemia and mouse mortality; higher doses were found to be less effective. Tested in vitro against three P. falciparum isolates, two chloroquine resistant and one meoquine resistant, the plants cultivated under standard conditions, and in humus enriched soil, were active; but the wild plants were the most active. Analysis using thin layer chromatography demonstrated the presence of avonoids (compounds considered responsible for the antimalarial activity) in all plants tested, even though at different proles. Because B. pilosa is proven to be active against P. falciparum drug‐resistant parasites in vitro , and in rodent malaria in vivo , it is a good candidate for pre‐clinical tests as a phytotherapeutic agent or for chemical isolation of the active compounds with the aim of nding new antimalarial drugs. Copyright © 2004 John Wiley & Sons, Ltd.