Two ellagitannins from the leaves of  Terminalia triﬂora  with inhibitory activity on HIV‐1 reverse transcriptase | Zendy

Martino V. | Zendy; Morales J. | Zendy; MartínezIrujo J. J. | Zendy; Font M. | Zendy; Monge A. | Zendy; Coussio J. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Two ellagitannins from the leaves of Terminalia triﬂora with inhibitory activity on HIV‐1 reverse transcriptase

Author(s) -

Martino V.,

Morales J.,

MartínezIrujo J. J.,

Font M.,

Monge A.,

Coussio J.

Publication year - 2004

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1504

Subject(s) - reverse transcriptase , pharmacognosy , terminalia , traditional medicine , chemistry , fractionation , inhibitory postsynaptic potential , stereochemistry , human immunodeficiency virus (hiv) , bioassay , biological activity , biology , biochemistry , chromatography , in vitro , virology , rna , medicine , genetics , neuroscience , gene

The bioassay‐ guided fractionation of the aqueous extract of Terminalia triora leaves afforded punicalin and 2‐ O ‐galloylpunicalin, isolated for the rst time from this species. These compounds showed inhibitory activity on HIV‐1 reverse transcriptase in a dose dependant manner. Punicalin showed an IC 50 of 0.11 µg/ml (0.14 µM) and 2‐ O ‐galloylpunicalin an IC 50 of 0.10 µg/ml (0.11 µM). Copyright © 2004 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research