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Two ellagitannins from the leaves of Terminalia triflora with inhibitory activity on HIV‐1 reverse transcriptase
Author(s) -
Martino V.,
Morales J.,
MartínezIrujo J. J.,
Font M.,
Monge A.,
Coussio J.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1504
Subject(s) - reverse transcriptase , pharmacognosy , terminalia , traditional medicine , chemistry , fractionation , inhibitory postsynaptic potential , stereochemistry , human immunodeficiency virus (hiv) , bioassay , biological activity , biology , biochemistry , chromatography , in vitro , virology , rna , medicine , genetics , neuroscience , gene
The bioassay‐ guided fractionation of the aqueous extract of Terminalia triora leaves afforded punicalin and 2‐ O ‐galloylpunicalin, isolated for the rst time from this species. These compounds showed inhibitory activity on HIV‐1 reverse transcriptase in a dose dependant manner. Punicalin showed an IC 50 of 0.11 µg/ml (0.14 µM) and 2‐ O ‐galloylpunicalin an IC 50 of 0.10 µg/ml (0.11 µM). Copyright © 2004 John Wiley & Sons, Ltd.