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In vitro leishmanicidal activity of some scarce natural products
Author(s) -
Takahashi Marii,
Fuchino Hiroyuki,
Sekita Setsuko,
Satake Motoyoshi
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1502
Subject(s) - diarylheptanoids , chemistry , fern , traditional medicine , dammarane , in vitro , biological activity , triterpenoid , stereochemistry , biology , biochemistry , botany , triterpene , medicine , alternative medicine , pathology
Leishmanicidal activity of 46 natural products including several fern and Betula constituents was examined. Several pterosin and atisene compounds from ferns had high activity. Among the triterpenoids the carboxyl group was found to be important for activity. In the diarylheptanoids, the linear‐type and the diphenylether‐type showed signicant activity, and it was found that the carbonyl group at C‐11 is necessary for the activity of biphenyl‐types. Copyright © 2004 John Wiley & Sons, Ltd.