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Hepatoprotective activity of Centaurium erythraea on acetaminophen‐induced hepatotoxicity in rats
Author(s) -
Mroueh Mohamad,
Saab Yolande,
Rizkallah Raed
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1498
Subject(s) - acetaminophen , lactate dehydrogenase , toxicity , gentianaceae , pharmacology , transaminase , glutamate dehydrogenase , chemistry , aspartate transaminase , traditional medicine , biochemistry , biology , enzyme , medicine , glutamate receptor , alkaline phosphatase , botany , receptor , organic chemistry
The methanol extract of the leaves of Centaurium erythraea L. (Gentianaceae) was evaluated for hepatoprotective activity against acetaminophen‐induced liver toxicity in rats. An oral dose of 300 mg/kg/day for 6 days or a single dose of 900 mg/kg for 1 day exhibited a signicant protective effect by lowering serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH). The activity of the extract was supported by histopathological examination of liver sections. Copyright © 2004 John Wiley & Sons, Ltd.