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The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro : a preliminary study
Author(s) -
Jagetia Ganesh Chandra,
Rao Shaival Kamalaksh,
Baliga Manjeshwar Shrinath,
S. Babu Kiran
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1494
Subject(s) - nitric oxide , pharmacology , peroxynitrite , sodium nitroprusside , traditional medicine , potency , medicine , in vitro , scavenging , chemistry , antioxidant , biochemistry , superoxide , enzyme , endocrinology
The nitric oxide (NO) scavenging activities of traditional polyherbal drugs like abana, chyavanaprasha, geriforte, septilin, mentat and triphala were examined using sodium nitroprusside as a NO donor in vitro . All the drugs tested demonstrated direct scavenging of NO and were superior to Gingko biloba , which was used as a positive control. The extracts of various polyherbal drugs exhibited dose‐dependent NO scavenging activities and the potency was in the following order: abana > chyavanaprasha > triphala > geriforte > septilin > mentat > Gingko biloba . The present results suggest that the traditional Indian polyherbal crude drugs may be potent and novel therapeutic agents for scavenging of NO, and thereby inhibit the pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite. These ndings may also help to explain, at least in part, the pharmacological activities like rejuvenating, adaptogenic, anti‐infection, anti‐inammatory, cardioprotective and neuroprotective activities of these traditional, clinically used non toxic drugs. Copyright © 2004 John Wiley & Sons, Ltd.