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Antiviral activity of the red marine alga Ceramium rubrum
Author(s) -
Serkedjieva Julia
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1458
Subject(s) - virus , microbiology and biotechnology , biology , herpes simplex virus , virology , intracellular , hemagglutinin (influenza) , in vitro , viral replication , biochemistry
An extract from the red marine alga Ceramium rubrum (Huds.) Ag. from the Bulgarian Black Sea seacoast considerably inhibited the reproduction of inuenza viruses type A and B in vitro and in ovo . The virus‐induced cytopathogenic effect (CPE), infectious virus yields and the production of hemagglutinin were all reduced at non‐toxic concentrations of the extract. The virus‐inhibitory effect was selective, dose‐related and strain‐specic; selectivity indices ranged 9.5–68.3. The inhibition affected adsorption as well as the intracellular stages of viral replication. The extract inhibited also the reproduction of herpes simplex virus (HSV) type 1 and type 2 in cell cultures. The preparation exhibited a strong HSV‐inactivating activity. Copyright © 2004 John Wiley & Sons, Ltd.