Antiviral activity of the red marine alga  Ceramium rubrum | Zendy

Serkedjieva Julia | Zendy

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Antiviral activity of the red marine alga Ceramium rubrum

Author(s) -

Serkedjieva Julia

Publication year - 2004

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1458

Subject(s) - virus , microbiology and biotechnology , biology , herpes simplex virus , virology , intracellular , hemagglutinin (influenza) , in vitro , viral replication , biochemistry

An extract from the red marine alga Ceramium rubrum (Huds.) Ag. from the Bulgarian Black Sea seacoast considerably inhibited the reproduction of inuenza viruses type A and B in vitro and in ovo . The virus‐induced cytopathogenic effect (CPE), infectious virus yields and the production of hemagglutinin were all reduced at non‐toxic concentrations of the extract. The virus‐inhibitory effect was selective, dose‐related and strain‐specic; selectivity indices ranged 9.5–68.3. The inhibition affected adsorption as well as the intracellular stages of viral replication. The extract inhibited also the reproduction of herpes simplex virus (HSV) type 1 and type 2 in cell cultures. The preparation exhibited a strong HSV‐inactivating activity. Copyright © 2004 John Wiley & Sons, Ltd.

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