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Prevention of bone loss by oil extract of garlic ( Allium sativum Linn.) in an ovariectomized rat model of osteoporosis
Author(s) -
Mukherjee M.,
Das A. S.,
Mitra S.,
Mitra C.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1448
Subject(s) - ovariectomized rat , allium sativum , osteoporosis , garlic oil , endocrinology , medicine , alkaline phosphatase , bone resorption , creatinine , calcium , acid phosphatase , chemistry , bone remodeling , hydroxyproline , bone mineral , estrogen , biochemistry , biology , food science , botany , enzyme
The effects of oil extract of garlic ( Allium sativum Linn.) on different primary and secondary osteoporotic marker changes were tested in an ovariectomized rat model of osteoporosis. Experiments were performed on three different rat models: sham‐operated control, ovariectomized and ovariectomized supplemented with garlic oil. In ovariectomized group, there has been a signicant increase in different relative organ weights compared to sham‐operated control, while the uterine weight was found to be decreased. Supplementation with oil extract of garlic could effectively reverse these changes. Also low bone densities that developed in the ovariectomized group were signicantly recovered in the garlic oil supplemented group. In our study, the development of high rate of bone turnover and osteoporosis in the ovariectomized animals were conrmed by signicant alteration of serum alkaline phosphatase activity, serum tartrate resistant acid phosphatase activity, urinary excretion of calcium, phosphate, hydroxyproline and urinary calcium to creatinine ratio, when compared with the sham‐operated control group. Garlic oil extract supplementation, apart from its unique inuence in lowering blood cholesterol, could also prevent ovariectomy‐induced rise in all the above‐mentioned marker changes. The results of this study emphasize that oil extract of garlic possibly has a positive role in suppressing ovariectomy‐induced bone resorption. Copyright © 2004 John Wiley & Sons, Ltd.