Premium
Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines
Author(s) -
Poli F.,
Appendino G.,
Sacchetti G.,
Ballero M.,
Maggiano N.,
Ranelletti F. O.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1443
Subject(s) - cell culture , pharmacognosy , biology , chemistry , traditional medicine , biological activity , botany , pharmacology , stereochemistry , biochemistry , in vitro , medicine , genetics
Certain jaesekanadiol p‐hydroxy‐ and p‐methoxybenzoates – typical of Ferula communis and Ferula arrigonii sardinian plants – show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2 α ‐OH‐ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen‐binding sites (EBS) underlies this activity. Copyright © 2005 John Wiley & Sons, Ltd.