Antiproliferative effects of daucane esters from  Ferula communis  and  F. arrigonii  on human colon cancer cell lines | Zendy

Poli F. | Zendy; Appendino G. | Zendy; Sacchetti G. | Zendy; Ballero M. | Zendy; Maggiano N. | Zendy; Ranelletti F. O. | Zendy

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Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines

Author(s) -

Poli F.,

Appendino G.,

Sacchetti G.,

Ballero M.,

Maggiano N.,

Ranelletti F. O.

Publication year - 2005

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1443

Subject(s) - cell culture , pharmacognosy , biology , chemistry , traditional medicine , biological activity , botany , pharmacology , stereochemistry , biochemistry , in vitro , medicine , genetics

Certain jaesekanadiol p‐hydroxy‐ and p‐methoxybenzoates – typical of Ferula communis and Ferula arrigonii sardinian plants – show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2 α ‐OH‐ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen‐binding sites (EBS) underlies this activity. Copyright © 2005 John Wiley & Sons, Ltd.

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