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Antispasmodic activity of extracts and compounds of Acalypha phleoides Cav.
Author(s) -
Astudillo Adela,
Hong Enrique,
Bye Robert,
Navarrete Andrés
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1414
Subject(s) - antispasmodic , histamine , camphor , thymol , jejunum , traditional medicine , acetylcholine , ileum , chemistry , propranolol , pharmacology , guinea pig , inhibitory postsynaptic potential , essential oil , biology , medicine , biochemistry , food science , anesthesia , endocrinology
The aerial parts of Acalypha phleoides are usually prescribed in the Mexican traditional medicine for a variety of gastrointestinal complaints. The MeOH–CHCl 3 (1:1) extract of the aerial part of A. phleoides showed an inhibitory effect on the gastrointestinal propulsion of a charcoal meal in mice. In isolated guinea‐pig ileum, this extract produced a concentration dependent inhibition of the contractions induced by 5‐hydroxytryptamine, but it was unable to inhibit the contractions elicited by acetylcholine, histamine, KCl and BaCl 2 . This extract produced also a concentration dependent inhibition of the spontaneous pendular movement of the isolated rabbit jejunum. This inhibitory activity was partially blocked by propranolol. The essential oil, obtained from the aerial part of this plant, was more potent than the MeOH–CHCl 3 (1:1) extract in inhibiting the spontan‐eous pendular movement of the rabbit jejunum. Thymol, camphor and γ ‐terpinene were identied from the essential oil by GC‐MS. These monoterpenes showed antispasmodic activity in the rabbit jejunum preparation, thymol was the most active compound, followed by camphor and γ ‐terpinene. Thymol and camphor in high concentrations also showed tracheal relaxant properties, but γ ‐terpinene did not. These in vivo and in vitro results tend to support the traditional use of A. phleoides as an antispasmodic agent. Copyright © 2004 John Wiley & Sons, Ltd.