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Effect of Acanthopanax senticosus on lipoprotein lipase in 3T3‐L1 adipocytes
Author(s) -
Yang JeongYeh,
Lee KangSeop,
Kim MyungKon,
Moon SeongKeun,
Kang MiKyung,
Park ByungHyun,
Kim JongSuk,
Park JinWoo
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1413
Subject(s) - lipoprotein lipase , triglyceride , adipocyte , 3t3 l1 , lipase , endocrinology , in vitro , medicine , chemistry , tumor necrosis factor alpha , biological activity , heparin , biology , biochemistry , enzyme , adipose tissue , cholesterol
The effect of Acanthopanax senticosus (AS) leaves on lipoprotein lipase (LPL) was investigated in 3T3‐L1 adipocytes. A water extract of AS leaves increased the LPL activity in culture medium of adipocytes in a dose‐ and time‐dependent manner. The AS extract contained heparin‐like LPL releasing components, however, the increase of medium LPL activity was continued up until 12 h, in contrast to the rapid decline after heparin treatment. The increase of LPL mRNA was also observed after AS extract treatment, suggesting that LPL induction occurs at the transcriptional level. The AS extract could partially reverse the LPL suppression by tumour necrosis factor −α in 3T3‐L1 adipocytes. These results of an AS extract‐induced increase of LPL activity in vitro suggest the possible action of AS as a facilitator of plasma triglyceride clearance. Copyright © 2004 John Wiley & Sons, Ltd.