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Studies on psychopharmacological effects of Cleome viscosa Linn. extract in rats and mice
Author(s) -
Parimala Devi B.,
Boominathan R.,
Mandal Subhash C.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1409
Subject(s) - muscle relaxant , traditional medicine , pharmacology , medicine
Methanol extract of the entire plant Cleome viscosa Linn. (CVME) was evaluated for different psychopharmacological actions such as general behaviour, exploratory behaviour, muscle relaxant activity and phenobarbitone induced sleeping time and effects on normal body temperature in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y‐maze test, reduction in the muscle relaxant by rotarod, 30° inclined screen and traction tests and caused signicant lowering of body temperature. In addition, CVME signicantly potentiated the phenobarbitone‐induced sleeping time. Preliminary tests indicate that the methanol extract of Cleome viscosa Linn. in doses of 200–400 mg/kg has signicant psychopharmacological activity. Copyright © 2004 John Wiley & Sons, Ltd.