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Anti‐obesity action of Salix matsudana leaves (Part 1). Anti‐obesity action by polyphenols of Salix matsudana in high fat‐diet treated rodent animals
Author(s) -
Han LiKun,
Sumiyoshi Maho,
Zhang Jing,
Liu MoXiang,
Zhang XinFeng,
Zheng YiNan,
Okuda Hiromichi,
Kimura Yoshiyuki
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1404
Subject(s) - polyphenol , obesity , anti obesity , traditional medicine , biology , action (physics) , botany , food science , chemistry , medicine , antioxidant , biochemistry , endocrinology , physics , quantum mechanics
Abstract In preliminary experiments, polyphenol fractions prepared from the leaves of Salix matsudana reduced the elevation of the rat plasma triacylglycerol level at 3 and 4 h after oral administration of a lipid emulsion containing corn oil, at a dose of 570 mg/kg. The present study examined the anti‐obesity action of polyphenol fractions of S. matsudana leaves by testing whether the polyphenol fractions prevented the obesity induced by feeding a high‐fat diet to female mice for 9 weeks. Body weights at 2–9 weeks and the nal parametrial adipose tissue weights were signicantly lower in mice fed the high‐fat diet with 5% polyphenols of S. matsudana leaves than in those fed the high‐fat diet alone. The polyphenols of S. matsudana leaves also signicantly reduced the hepatic total cholesterol content, which was elevated in mice fed the high‐fat diet alone. In addition, the polyphenol fractions of S. matsudana leaves inhibited palmitic acid uptake into brush border membrane vesicles prepared from rat jejunum and α ‐amylase activity, and their fractions enhanced norepinephrine‐induced lipolysis in fat cells. In conclusion, it is suggested that the inhibitory effects of the avonoid glycoside fraction of S. matsudana leaves on high‐fat diet‐induced obesity might be due to the inhibition of carbohydrate and lipid absorption from small intestine through the inhibition of α ‐amylase and palmitic acid uptake into small intestinal brush border membrane or by accelerating fat mobilization through enhancing norepinephrine‐induced lipolysis in fat cells. Copyright © 2003 John Wiley & Sons, Ltd.