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Protonophoric and uncoupling activity of royleanones from Salvia officinalis and euvimals from Eucalyptus viminalis
Author(s) -
Spiridonov Nikolay A.,
Arkhipov Vladimir V.,
Foigel Alexander G.,
Shipulina Liudmila D.,
Fomkina Maria G.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1403
Subject(s) - salvia , cytotoxicity , terpenoid , chemistry , mechanism of action , biochemistry , biology , botany , in vitro
The mechanism of action of quinones from the roots of Salvia ofcinalis L. (royleanones) and terpenoid phenolaldehydes from the leaves of Eucalyptus viminalis Labill. (euvimals) was studied. Royleanones and euvimals displayed marked protonophoric activity on articial bilayer lipid membranes in vitro , and exerted an uncoupling action on oxidative phosphorylation in isolated rat liver mitochondria. The results suggest that biological membranes are the primary targets of royleanones and euvimals, and the protonophoric activity may contribute to the cytotoxicity and antimicrobial properties of these compounds. Copyright © 2003 John Wiley & Sons, Ltd.