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Effects of Paeonia lactiflora root extracts on the secretions of monocyte chemotactic protein‐1 and ‐3 in human nasal fibroblasts
Author(s) -
Leem K.,
Kim H.,
Boo Y.,
Lee H. S.,
Kim J. S.,
Yoo Y. C.,
Ahn H. J.,
Park H. J.,
Seo J. C.,
Kim H. K.,
Jin S. Y.,
Park H. K.,
Chung J. H.,
Cho J. J.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1392
Subject(s) - monocyte , chemokine , secretion , pharmacology , tumor necrosis factor alpha , chemotaxis , radix (gastropod) , interleukin 8 , paeonia lactiflora , cytokine , immunology , medicine , chemistry , biology , inflammation , receptor , pathology , botany , alternative medicine
In the eld of Oriental medicine, the root of Paeonia lactiora (Paeoniae Radix) has been prescribed usually to treat the common cold, and it was thought to alleviate upper respiratory infection or nasal inammation. Monocyte chemotactic proteins (MCP)‐1 and MCP‐3 are known as the most potent chemokines to mediate allergic inammation. The object of the study was to investigate the effect of Paeoniae Radix on the release of the chemokines such as MCP‐1 and MCP‐3. To detect the secretion of MCPs, an enzyme‐linked immunosorbent assay was performed for human nasal mucosal broblasts after stimulation with several cytokines such as tumor necrosis factor‐ α (TNF‐ α ), interferon‐ γ (IFN‐ γ ) and interleukin‐1 β (IL‐1 β ). The secretion of MCP‐1 was increased after stimulation with TNF‐ α or IL‐1 β treatment. Co‐treatment of TNF‐ α and IFN‐ γ , or IL‐1 β and IFN‐ γ increased the secretion of MCP‐1 and MCP‐3. Paeoniae Radix was tested with inammatory cytokines, and the results showed that the Paeoniae Radix signicantly decreased the secretion of MCP‐1 and MCP‐3. In our study, Paeoniae Radix may play an important role in nasal inammation with a modulation of MCP‐1 and MCP‐3. Copyright © 2004 John Wiley & Sons, Ltd.