Anti‐HIV‐1 limonoid: first isolation from  Clausena excavata | Zendy

Sunthitikawinsakul Arunrat | Zendy; Kongkathip Ngampong | Zendy; Kongkathip Boonsong | Zendy; Phonnakhu Sida | Zendy; Daly John W. | Zendy; Spande Thomas F. | Zendy; Nimit Yuth | Zendy; Napaswat Chanita | Zendy; Kasisit Jittra | Zendy; Yoosook Chalobon | Zendy

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Anti‐HIV‐1 limonoid: first isolation from Clausena excavata

Author(s) -

Sunthitikawinsakul Arunrat,

Kongkathip Ngampong,

Kongkathip Boonsong,

Phonnakhu Sida,

Daly John W.,

Spande Thomas F.,

Nimit Yuth,

Napaswat Chanita,

Kasisit Jittra,

Yoosook Chalobon

Publication year - 2003

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1381

Subject(s) - limonoid , rhizome , chemistry , stereochemistry , traditional medicine , chloroform , rutaceae , ethanol , pharmacognosy , biological activity , biology , biochemistry , botany , in vitro , chromatography , medicine

A limonoid, clausenolide‐1‐ethyl ether (1) and two coumarins, dentatin (2) and nor ‐dentatin (3), were isolated from Clausena excavata . Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from C. excavata and exhibited HIV‐1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti‐HIV‐1 substance, (+)‐calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti‐HIV‐1 activity. These compounds, 1–3, did not show any cytotoxic effect against KB and BC‐1 cell lines (IC 50 value > 20 µg/mL). Copyright © 2003 John Wiley & Sons, Ltd.

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