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Inhibitory effects of several flavonoids on E‐selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor‐ α
Author(s) -
TakanoIshikawa Yuko,
Goto Masao,
Yamaki Kohji
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1371
Subject(s) - apigenin , luteolin , umbilical vein , genistein , chalcone , tumor necrosis factor alpha , eriodictyol , kaempferol , chemistry , flavonoid , biology , biochemistry , stereochemistry , in vitro , immunology , genetics , antioxidant
The present study investigates the suppressive effect of avonoids on TNF‐ α ‐stimulated E‐selectin expression on HUVECs by carrying out a comparative examination of the 37 avonoids. Several avonoids: setin, luteolin and apigenin (subclass of avone), kaempferol and quercetin (avonols), eriodictyol (avanones), genistein (isoavones) and butein (chalcone) exhibit the inhibitory effects. Considerations to the structure of avonoids, the C2–C3 double bond of C‐ring and 4‐oxo functional group are essential for their inhibition activities. These results help to explain the pharmacological efcacy of avonoids as anti‐inammatory compounds. Copyright © 2003 John Wiley & Sons, Ltd.