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Supplementation of fenugreek leaves to diabetic rats. Effect on carbohydrate metabolic enzymes in diabetic liver and kidney
Author(s) -
Devi B. Anitha,
Kamalakkannan N.,
Prince P. Stanely Mainzen
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1357
Subject(s) - glibenclamide , diabetes mellitus , streptozotocin , trigonella , glycogen , medicine , traditional medicine , kidney , insulin , carbohydrate , phytotherapy , endocrinology , alternative medicine , pathology
The present study was designed to evaluate the effect of supplementation of fenugreek leaves, an indigenous plant widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus, in streptozotocin induced diabetic rats. Supplementation of the diet with fenugreek leaves showed a signicant effect on hyperglycaemia, hypoinsulinaemia and glycosylated haemoglobin in streptozotocin diabetic rats. Fenugreek leaves improved the body weight and liver glycogen. Fenugreek leaves also showed a signicant effect on key carbohydrate metabolic enzymes in diabetic rats. The effect of fenugreek leaves was found to be similar to that of glibenclamide. Thus, fenugreek leaves exhibited antidiabetic action in streptozotocin‐induced diabetic rats. Insulin restored all the parameters to near normal levels in diabetic rats. Copyright © 2003 John Wiley & Sons, Ltd.