Premium
Antiproliferative activity of Copaifera duckei oleoresin on liver regeneration in rats
Author(s) -
CastroeSilva Orlando,
Zucoloto Sérgio,
Ramalho Fernando S.,
Ramalho Leandra N. Z.,
Reis José M. C.,
Bastos Álvaro A. C.,
Brito Marcus V. H.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1351
Subject(s) - respiration , saline , stimulation , pharmacology , medicine , traditional medicine , liver regeneration , oxidative phosphorylation , mitochondrion , apoptosis , chemistry , biochemistry , endocrinology , biology , regeneration (biology) , anatomy , microbiology and biotechnology
Copaiba oleoresin is widely used in folk medicine as an antiinammatory, healing and antiseptic agent. Wistar rats received Copaifera duckei oleoresin (CDO) or saline solution (SS) from 7 days before surgery until killing. Partial hepatectomy (PH) or sham‐operation was performed. Hepatocellular proliferation and liver mitochondrial respiration were evaluated 24 h after the procedure. The proliferating cell nuclear antigen labelling index was signicantly lower in CDO‐treated plus PH rats than in SS‐treated plus PH rats, suggesting that CDO inhibited cell proliferation. The state 3 and state 4 respiration rates were greater for CDO‐treated groups, and the stimulation of state 4 respiration was more expressive. These data resulted in a signicant decrease in the respiratory control ratio observed for CDO‐treated groups, demonstrating the ability of CDO to uncouple oxidative phosphorylation in mitochondria, a fact that may be one explanation for the inhibition of hepatocellular proliferation observed in the CDO‐treated plus PH group. Copyright © 2004 John Wiley & Sons, Ltd.