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Vasodilating properties of the stem bark extract of Mitragyna ciliata in rats and guinea pigs
Author(s) -
Dongmo A.,
Kamanyi M. A.,
Tan P. V.,
Bopelet M.,
Vierling W.,
Wagner H.
Publication year - 2004
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1350
Subject(s) - ciliata , guinea pig , vasodilation , pharmacognosy , traditional medicine , pharmacology , medicine , endothelium , muscle relaxant , chemistry , botany , biology , biological activity , biochemistry , protozoa , in vitro
Mitragyna ciliata is commonly used in traditional medicine for the treatment of inammation, hypertension, headache, rheumatism, gonorrhoea and broncho‐pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea‐pig was investigated. The extract induced aortic relaxation in a concentration‐dependent manner, with an EC 50 of 1.3 and 7 µg/mL for the noradrenaline‐ and KCl‐induced contractions, respectively. The relaxant effect of the extract on KCl‐induced contractions was ve times greater than on noradrenaline‐induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and avonoids which may be responsible for the antihypertensive properties. Copyright © 2004 John Wiley & Sons, Ltd.