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Antimicrobial activities of Barringtonia acutangula
Author(s) -
Rahman M. Mukhlesur,
Polfreman David,
MacGeachan Jodie,
Gray Alexander I.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1341
Subject(s) - antimicrobial , broth microdilution , aspergillus niger , petroleum ether , traditional medicine , biology , microbiology and biotechnology , gram positive bacteria , bacteria , minimum inhibitory concentration , chemistry , food science , medicine , chromatography , extraction (chemistry) , genetics
Abstract Crude extracts and VLC fractions from the stem bark of Barringtonia acutangula (L.) Gaertn (Fam. Lecythidaceae) were screened for their antimicrobial activities against two Gram‐positive bacteria, two Gram‐negative bacteria and two fungi using a microdilution titre assay. Among the crude extracts, petroleum ether extract showed good activity against all test organisms. The VLC fraction PE 16 was found to be very effective against Bacillus subtilis (MIC = 25 µg/ml) and Aspergillus niger (MIC = 12.5 µg/ml). The activities were compared to standard antibiotics‐kanamycin and fluconazole. The major compound from PE16 was identified as 12, 20(29)‐lupadien‐3‐ol by NMR spectroscopy. Copyright © 2005 John Wiley & Sons, Ltd.