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Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses
Author(s) -
García D.,
Leiro J.,
Delgado R.,
Sanmartín M. L.,
Ubeira F. M.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1338
Subject(s) - mangiferin , mangifera , immune system , traditional medicine , pharmacognosy , humoral immunity , biology , phytotherapy , immunology , medicine , biological activity , pharmacology , botany , in vitro , biochemistry , alternative medicine , pathology
The present study investigated the effects of orally administered Vimang (an aqueous extract of Mangifera indica ) and mangiferin (the major polyphenol present in Vimang) on mouse antibody responses induced by inoculation with spores of microsporidian parasites. Inoculation induced specic antibody production with an exponential timecourse, peaking after about one month. Vimang signicantly inhibited this antibody production from about three weeks post‐inoculation, and most markedly by four weeks post‐inoculation; by contrast, mangiferin had no signicant effect. Determination of Ig isotypes showed that the IgM to IgG switch began about four weeks post‐inoculation, with IgG2a predominating. Vimang signicantly inhibited IgG production, but had no effect on IgM. Mangiferin did no affect either IgM or IgG2a, but signicantly enhanced production of IgG1 and IgG2b. Neither Vimang nor mangiferin enhanced specic antibody secretion by splenic plasma cells from mice inoculated with microsporidian spores, whether administered in vivo before serum extraction or in vitro to the culture medium. Inoculation with spores induced splenomegaly, which was signicantly reduced by Vimang and signicantly enhanced by mangiferin. These results suggest that components of Mangifera indica extracts may be of potential value for modulating the humoral response in different immunopathological disorders. Copyright © 2003 John Wiley & Sons, Ltd.