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Bioassay‐guided isolation and identification of antifungal compounds from ginger
Author(s) -
Ficker C.,
Smith M. L.,
Akpagana K.,
Gbeassor M.,
Zhang J.,
Durst T.,
Assabgui R.,
Arnason J. T.
Publication year - 2003
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1335
Subject(s) - bioassay , antifungal , traditional medicine , isolation (microbiology) , zingiber officinale , cultivar , biology , biological activity , chemistry , botany , medicine , biochemistry , microbiology and biotechnology , in vitro , ecology
A bioassay‐guided isolation of antifungal compounds from an African land race of ginger, Zingiber ofcinale Roscoe, led to the identication of [6], [8] and [10]‐gingerols and [6]‐gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race was at least 3 × higher than that of typical commercial cultivars of ginger. Therefore, ginger extracts standardized on the basis of the identied compounds, could be considered as antifungal agents for practical therapy. Copyright © 2003 John Wiley & Sons, Ltd.
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